Somatic mutations arising in human skin cancers are heterogeneously distributed across the genome, meaning that certain genomic regions (e.g., heterochromatin or transcription factor binding sites) have much higher mutation densities than others. Regional variations in mutation rates are typically not a consequence of selection, as the vast majority of somatic mutations in skin cancers are passenger mutations that do not promote cell growth or transformation. Instead, variations in DNA repair activity, due to chromatin organization and transcription factor binding, have been (...) proposed to be a primary driver of mutational heterogeneity in melanoma. However, as discussed in this review here, recent studies indicate that chromatin organization and transcription factor binding also significantly modulate the rate at which UV lesions form in DNA. The authors propose that local variations in lesion susceptibility may be an important driver of mutational hotspots in melanoma and other skin cancers, particularly at binding sites for ETS transcription factors. (shrink)

Whereas The Stag Hunt and the Evolution of Social Structure supplements Evolution of the Social Contract by examining some of the earlier work’s strategic problems in a local interaction setting, no equivalent supplement exists for The Dynamics of Rational Deliberation . In this article, I develop a general framework for modeling the dynamics of rational deliberation in a local interaction setting. In doing so, I show that when local interactions are permitted, three interesting phenomena occur: (a) the attracting deliberative equilibria (...) may fail to agree with any of the Nash equilibria of the underlying game, (b) deliberative dynamics which converged to the same deliberative outcome in The Dynamics of Rational Deliberation may lead to different deliberative outcomes here, and (c) Bayesian deliberation seems to be more likely to avoid nonstandard deliberative outcomes, contrary to the result reported in The Dynamics of Rational Deliberation , which argued in favour of the Brown–von Neumann–Nash dynamics. (shrink)

At the very end of the 19th century, Gabriele Tarde wrote that all society was a product of imitation and innovation. This view regarding the development of society has, to a large extent, fallen out of favour, and especially so in those areas where the rational actor model looms large. I argue that this is unfortunate, as models of imitative learning, in some cases, agree better with what people actually do than more sophisticated models of learning. In this paper, I (...) contrast the behaviour of imitative learning with two more sophisticated learning rules (one based on Bayesian updating, the other based on the Nash-Brown-von Neumann dynamics) in the context of social deliberation problems. I show for two social deliberation problems, the Centipede game and a simple Lewis sender-receiver game, that imitative learning provides better agreement with what people actually do, thus partially vindicating Tarde. (shrink)

This handbook presents a comprehensive introduction to the core areas of philosophy of education combined with an up-to-date selection of the central themes. It includes 95 newly commissioned articles that focus on and advance key arguments; each essay incorporates essential background material serving to clarify the history and logic of the relevant topic, examining the status quo of the discipline with respect to the topic, and discussing the possible futures of the field. The book provides a state-of-the-art overview of philosophy (...) of education, covering a range of topics: Voices from the present and the past deals with 36 major figures that philosophers of education rely on; Schools of thought addresses 14 stances including Eastern, Indigenous, and African philosophies of education as well as religiously inspired philosophies of education such as Jewish and Islamic; Revisiting enduring educational debates scrutinizes 25 issues heavily debated in the past and the present, for example care and justice, democracy, and the curriculum; New areas and developments addresses 17 emerging issues that have garnered considerable attention like neuroscience, videogames, and radicalization. The collection is relevant for lecturers teaching undergraduate and graduate courses in philosophy of education as well as for colleagues in teacher training. Moreover, it helps junior researchers in philosophy of education to situate the problems they are addressing within the wider field of philosophy of education and offers a valuable update for experienced scholars dealing with issues in the sub-discipline. Combined with different conceptions of the purpose of philosophy, it discusses various aspects, using diverse perspectives to do so. Contributing Editors: Section 1: Voices from the Present and the Past: Nuraan Davids Section 2: Schools of Thought: Christiane Thompson and Joris Vlieghe Section 3: Revisiting Enduring Debates: Ann Chinnery, Naomi Hodgson, and Viktor Johansson Section 4: New Areas and Developments: Kai Horsthemke, Dirk Willem Postma, and Claudia Ruitenberg. (shrink)

The Racial and Religious Hatred Act 2006 represents a significant development in UK law. It extends the offence of incitement to racial hatred set out in the Public Order Act 1986 to make it also an offence to stir up hatred against persons on religious grounds. As the most celebrated liberal thinker of the nineteenth century, J.S. Mill might be expected to offer some lessons about the possible dangers of this sort of legislation. A Millian response to the 2006 Act (...) is developed here by first applying Mill’s famous defence of free speech to the Lords amendments to the Racial and Religious Hatred Bill 2005 and then by looking at potential cases in which even freedom of expression loses its immunity when this is necessary to prevent harm to others. Three versions of the harm‐prevention justification for liberty‐limiting restrictions are assessed and it is argued that the most promising version is the claim that it may be permissible to punish incitement to racial and religious hatred not so much because it is itself a kind of harm but by virtue of the acts of discrimination, violence and injustice that are more likely to occur within a climate of hatred. Ultimately, however, this rationale must be weighed against what is, for Mill, the special value of free speech and may in the end justify intervention in only the most acute cases. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

The General Data Protection Regulation (GDPR) of the EU confirms the protection of personal data as a fundamental human right and affords data subjects more control over the way their personal information is processed, shared, and analyzed. However, where data are processed by artificial intelligence (AI) algorithms, asserting control and providing adequate explanations is a challenge. Due to massive increases in computing power and big data processing, modern AI algorithms are too complex and opaque to be understood by most data (...) subjects. Articles 15 and 22 of the GDPR provide a modest regulatory framework for automated data processing by, among other things, mandating that data controllers inform data subjects about when it is being used, and its logic and ramifications. Nevertheless, due to the phrasing of the articles and the numerous exceptions they allow, doubts have arisen about their effectiveness. In this paper, we empirically evaluate the quality and effectiveness of AI disclosures as mandated by the GDPR. By means of an online survey (N = 835), we investigated how data subjects expect to be informed about the automated processing of their data. We then conducted a content analysis of the AI disclosures of N = 100 companies and organizations. The combined findings reveal that current GDPR-mandated disclosures do not meet the expectations and needs of data subjects. Explanations drawn up following the guidelines of the generic formulations of the GDPR differ widely and are often vague, incomplete and lack transparency. In our conclusions we identify a path towards standardizing and optimizing AI information notices. (shrink)

It is certainly the case that morality governs the interactions that take place between individuals. But what if morality exists because of these interactions? This book, first published in 2007, argues for the claim that much of the behaviour we view as 'moral' exists because acting in that way benefits each of us to the greatest extent possible, given the socially structured nature of society. Drawing upon aspects of evolutionary game theory, the theory of bounded rationality, and computational models of (...) social networks, it shows both how moral behaviour can emerge in socially structured environments, and how it can persist even when it is not typically viewed as 'rational' from a traditional economic perspective. This book also provides a theory of how moral principles and the moral sentiments play an indispensable role in effective choice, acting as 'fast and frugal heuristics' in social decision contexts. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in (...) the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Jacobi held a position of unparalleled importance in late eighteenth and early nineteenth century intellectual history. This includes his role in bringing about the close of the Enlightenment, his central part in shaping the reception of Kant's philosophy and German idealism, and his influence on the development of Romanticism and existentialism.

In this wide-ranging conversation, Michael Hardt reflects on recent transformations within Empire. Several unique themes emerge concerning power and pedagogy as they intersect with subjectivity and global crisis. Drawing on the common in conjunction with the tradition of love in education uncovers a different path that attends to today’s real political, ecological, and social needs. Finally, a focus on collectivity points to a possible strategy—collective intellectuality—for educators to revise traditional notions of leadership to encourage more ethical, democratic, and sustainable futures. (...) Yet, what this looks like in practice remains for us to imagine. (shrink)

We provide a new wrinkle to the Argument from Unfair Advantage, a rather popular one in the ethics of doping in sports discussions. But we add a new argument that we believe places the moral burden on those who favor doping in sports. We also defend our position against some important concerns that might be raised against it. In the end, we argue that for the time being, doping in sports ought to be banned until it can be demonstrated that (...) our concerns can be satisfied. (shrink)

Early German Romanticism sought to respond to a comprehensive sense of spiritual crisis that characterised the late eighteenth century. The study demonstrates how the Romantics sought to bring together the new post-Kantian idealist philosophy with the inheritance of the realist Platonic-Christian tradition. With idealism they continued to champion the individual, while from Platonism they took the notion that all reality, including the self, participated in absolute being. This insight was expressed, not in the language of theology or philosophy, but through (...) aesthetics, which recognised the potentiality of all creation, including artistic creation, to disclose the divine. In explicating the religious vision of Romanticism, this study offers a new historical appreciation of the movement, and furthermore demonstrates its importance for our understanding of religion today. (shrink)

Platonism has played a central role in Christianity and is essential to a deep understanding of the Christian theological tradition. At times, Platonism has constituted an essential philosophical and theological resource, furnishing Christianity with an intellectual framework that has played a key role in its early development, and in subsequent periods of renewal. Alternatively, it has been considered a compromising influence, conflicting with the faith's revelatory foundations and distorting its inherent message. In both cases the fundamental importance of Platonism, as (...) a force which Christianity defined itself by and against, is clear. Written by an international team of scholars, this landmark volume examines the history of Christian Platonism from antiquity to the present day, covers key concepts, and engages issues such as the environment, natural science and materialism. (shrink)

This paper attempts to situate Thomas Aquinas with respect to philosophical discussions of the nature of metaphorical language. I consider Aquinas’s comments in the Summa Theologiae on Scriptural metaphor and allegory in the light of two theses in current discussions of metaphor: the substitution thesis and the dual-meaning thesis. I compare Aquinas’s view to those of Aristotle and Donald Davidson. The substitution thesis asserts that figurative expressions can be replaced by semantically equivalent literal expressions. The dual-meaning thesis asserts that, in (...) addition to a literal meaning (or sense), metaphorical language possesses another meaning, viz. a figurative one. I claim that Aquinas’s view is complex. He affirms the dual-meaning thesis with regard to Scriptural allegory. Yet he rejects the dual-meaning thesis and affirms the substitution thesis with regard to predicates ascribed metaphorically to God. (shrink)

Appeals to human nature are ubiquitous, yet historically many have proven ill-founded. Why? How might frequent errors be remedied towards building a more robust and reliable scientific study of human nature? Our aim is neither to advance specific scientific or philosophical claims about human nature, nor to proscribe or eliminate such claims. Rather, we articulate through examples the types of errors that frequently arise in this field, towards improving the rigor of the scientific and social studies. We seek to analyze (...) such claims rhetorically, cognitively, and epistemically. Namely, how do we think about human nature? Claims about human nature, we show, are susceptible to widely exhibited deficits in cognitive tendencies such as framing, confirmation bias, satisficing, and teleological perspectives, as well as motivated reasoning. Such missteps foster methodological, empirical, and psychological mistakes and biases. Specifically, they promote the naturalizing error, whereby cultural ideology and values are projected onto an apparently objective description of nature. Concrete remedies are offered to aid scientists in conducting and reporting their research goals and findings more responsibly and effectively (relevant also to educators and other communicators who convey these findings publicly). Recommendations include acknowledging that human nature claims are often context-dependent, seeking multiple critical perspectives, and explicitly labeling uncertainties. (shrink)

Recent years have seen increased interest in the question of whether it is possible to provide an evolutionary game-theoretic explanation for certain kinds of social norms. I sketch a proof of a general representation theorem for a large class of evolutionary game-theoretic models played on a social network, in hope that this will contribute to a greater understanding of the long-term evolutionary dynamics of such models, and hence the evolution of social norms.

In this volume, critical scholars and educational activists explore the intricate dynamics between the enclosure of global commons and radical visions of a common social future that breaks through the logics of privatization, ecological degradation, and dehumanizing social hierarchies in education. In its institutional and informal configurations alike, education has been identified as perhaps the key stake in this struggle. Insisting on the urgency of an education that breaks free of the bonds of enclosure, the essays included in this volume (...) weave together bright threads of radical thought into a vivid tapestry illustrating a critical framework for enacting a global educational commons. (shrink)

Die Musikpädagogik als Disziplin begann sich erst Anfang des 19. Jahrhunderts zu konstituieren. Gleichwohl hat Johann Gottfried Herder zahlreiche musikpädagogische Ideen benannt und reflektiert. Als leidenschaftlicher Musikliebhaber und Pädagoge kreisten seine Gedanken in retrospektiver Ferne und interkultureller Weite, ohne theoriebildenden Anspruch für die Musikerziehung zu erheben. Dennoch wurde Herder häufig als Gewährsmann verschiedener ideologischer Perspektiven bemüht. Die Studie will sachlich, ehrlich und unbefangen aufräumen, indem sie erstens Herders Spuren zur Erziehung durch Musik gründlich folgt, zweitens Irrtümer sowie Missdeutungen aus dem (...) Weg räumt, um drittens Herder als Wegbereiter durch Dokumentation seiner immensen Rezeption zu würdigen. (shrink)

Largely neglected today, the work of Karl Philipp Moritz was a highly influential source for Early German Romanticism. Moritz considered the form of myth as essential to the absolute nature of the divine subject. This defence was based upon his aesthetic theory, which held that beautiful art was “disinterested”, or complete in itself. For Moritz, Myth, like art, constitutes a totality providing an idiom free from restriction in the imitation of the divine. This examination offers a consideration of Moritz’s aesthetics (...) and mythography, before turning briefly to consider his influence on the authors of Early German Romanticism. An understanding of the role of Moritz’s thought supports a number of recent claims that challenge the conventional reading of Romanticism. At the same time it allows us to see Romanticism’s unconventional realist theological programme, permitting us to overcome the problematic secularising readings of the movement. I would like to thank Kurt Mueller-Vollmer, as well as Fredrick Beiser and Lars Fischer for their help with this project. (shrink)

Decision theory faces a number of problematic gambles which challenge it to say what value an ideal rational agent should assign to the gamble, and why. Yet little attention has been devoted to the question of what an ideal rational agent is, and in what sense decision theory may be said to apply to one. I show that, given one arguably natural set of constraints on the preferences of an idealized rational agent, such an agent is forced to be indifferent (...) among entire families of goods, and hence cannot choose among them. This result illustrates the dangers of speaking of the choices of an ?ideal rational agent? when one does not make precise the exact nature of the idealizing assumptions. The result may also be viewed as providing an upper bound on the kinds of idealizing assumptions which can be made for rational agents, beyond which the very concept of choice becomes attenuated. (shrink)

This thesis concerns the relation between the fundamental properties and the powers they confer. The views considered are introduced in terms of their acceptance or rejection of the quiddistic thesis. Essentially the quiddistic thesis claims that properties confer the powers they do neither necessarily nor sufficiently. Quidditism is the view that accepts the quiddistic thesis. The other two views to be considered, the pure powers view and the grounded view reject the quiddistic thesis. The pure powers view supports its denial (...) of the quiddistic thesis with the claim that properties consist in conferring the powers they do; the possession of a property just is the possession of a power. The grounded view, the positive view of this thesis, rejects the idea that properties are constituted by conferring the causal powers they do. Rather on the grounded view, it is the natures of the fundamental properties that metaphysically explain why they confer the powers they do. (shrink)

As it emerged in the late twentieth century, Empire promised a new era of global cooperation and stability through a seamless integration of late capitalism and neoliberal technocracy. Premised as an end to history itself, all that was left to accomplish was to tinker at the margins, stimulate corporate enterprise, embrace financialization and technological innovation, and encourage liberal rights and inclusion. As we enter the third decade of the twenty-first century, the narrative fictions sustaining Empire have broadly collapsed at the (...) level of symbolic identification and belief. Empire has entered into a period of global emergency and mutation. Engaging with Michael Hardt and Antonio Negri’s work, this paper considers what might emerge when we read education into the circuitry of Empire’s decay. First, we locate Empire within foundational tensions in modernity, using Kantian philosophy and colonialism as examples, to foreground the idea of education as immanent to historical processes of creativity, resistance, and innovation. Second, we highlight dead-end responses, from space colonization to neo-fascism, as representations of how modes of education circulate to stabilize and contain Empire’s crises, specifically in relation to capitalism, nationalism, and identity. Lastly, the paper develops a political ontology of education after Empire. (shrink)

The concept of biopolitics was first outlined by Michel Foucault (2003, 2007, 2009) in his lectures at the Collège de France in the late 1970s in order to name and analyze emergent logics of power...

The food industry faces many significant risks from public criticism of corporate social responsibility (CSR) issues in the supply chain. This paper draws upon previous research and emerging industry trends to develop a comprehensive framework of supply chain CSR in the industry. The framework details unique CSR applications in the food supply chain including animal welfare, biotechnology, environment, fair trade, health and safety, and labor and human rights. General supply chain CSR issues such as community and procurement are also considered. (...) Ultimately, the framework serves as a comprehensive tool to support food industry practitioners and researchers in the assessment of strategic and operational supply chain CSR practices. (shrink)